A case of Long QT syndrome

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[A case of long QT syndrome].

Introduction Long QT syndrome (LQTS) is a group of genetically distinct arrhythmogenic disorders resulting in abnormal cardiac sodium and potassium ion channels causing delayed repolarization of the heart. This syndrome can present clinically as syncope, seizures, or sudden cardiac death secondary to its characteristic ventricular arrhythmia of torsades de pointes. The clinical and electrocardi...

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Allelic Complexity in Long QT Syndrome: A Family-Case Study

Congenital long QT syndrome (LQTS) is associated with high genetic and allelic heterogeneity. In some cases, more than one genetic variant is identified in the same (compound heterozygosity) or different (digenic heterozygosity) genes, and subjects with multiple pathogenic mutations may have a more severe disease. Standard-of-care clinical genetic testing for this and other arrhythmia susceptib...

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Clarithromycin-Induced Long QT Syndrome: A Case Report

Long QT syndrome develops for a number of reasons. The number of non-antiarrhythmic drugs reported to induce QT interval prolongation with or without torsade de pointes continues to increase. Clarithromycin is a macrolide antibiotic being increasingly used for the treatment of atypical pneumonia. In this paper, we describe a patient who developed long QT prolongation syndrome after receiving cl...

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Long QT Syndrome

Background. Erythromycin is known to prolong ventricular repolarization and has been associated with the occurrence of torsades de pointes. In this study, we have investigated potential mechanisms in vivo and in vitro for induction of an acquired long QT syndrome by erythromycin. Methods and Results. Ventricular electrograms and endocardial monophasic action potentials were recorded in anesthet...

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The Long QT Syndrome

Introduction The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the "primary cardiac arrhythmias" or "cardiac ion channelopathies". The study of inherited LQTS has prov...

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ژورنال

عنوان ژورنال: Sri Lanka Journal of Child Health

سال: 2016

ISSN: 2386-110X,1391-5452

DOI: 10.4038/sljch.v45i2.8094